Molecular Evolutionary Models in Drug Discovery

Molecular evolution is the process of changes in DNA, RNA, and proteins that occur in living organisms across generations. The changes in these organisms occur through interaction and communication with environmental factors that favor adaptation. This process also changes the metabolomics of a species as well as the activity of secondary metabolites and their interaction with different ecosystems. Molecular Evolution Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation. They are the result of the interaction of genes, metabolism, and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings. They can serve as an innovative tool to obtain information that leads to promising applications in the diagnosis of diseases, drug development, and drug discovery Examines the integration and application of evolutionary models in the pharmaceutical industry to create new drug development platforms Investigates the biotechnological prospecting of secondary metabolites and their potential use in the discovery of new drugs Evaluates the ecosystem of living beings and how its molecular adaptation might improve the success of therapies